Harlequin Ichthyosis is one of the most mysterious diseases of the world. It is also called “HARLEQUIN BABY”. It is popularly known as a skin disease. It happens due to the thickening of Keratin in human skin. Due to this disease the skin contains massive diamond shapes and skin takes reddish color. Due to this disease eyes, ear and penis increase abnormally. It is easily attracted by bacteria and it causes infection. Harlequin type generally appears in baby’s face and the serious hyperkeratosis helps to cause diamond shape in skin.